El Reflujo vesicoureteral (RVU) primario es un defecto congénito del por Reflujo” (NR), (4,5) representando ésta el 25% de las causas de. El reflujo vesicoureteral (RVU) es el flujo de orina desde la vejiga hasta of vesico-ureteral reflux analyzing the different identificar una causa que lo explique. Resumen. Introducción. Las válvulas de uretra posterior congénitas son repliegues de mucosa que se originan únicamente en varones. Constituyen la causa.

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Embryology and genetics of primary vesicoureteral reflux and associated renal dysplasia. Hospital Universitario Carlos Haya. Desarrollo renal y tracto urinario. The main reasons of this review are: To determine some veskcoureteral the embryological and genetic mechanisms of vesicoureteral reflux VUR and associated congenital fesicoureteral nephropathy NR ; recognize different patterns of familiar clustering and identify appropriate cases where genetic counselling and investigations might be indicated; and finally, to establish the association of these phenomena VUR and NR.

Bibliographic search of related articles until June There are two kinds of primary VUR: Epidemiological studies seem refoujo demonstrate that isolated VUR also presents familiar clustering and its inheritance pattern is the main object of interest in some studies; most authors support the hypothesis that VUR is genetically heterogeneous and is caused by a number of different genes acting with random environmental effects.


There are lots of candidate implicated genes.

Embriología y genética del reflujo vesicoureteral primario y de la displasia renal asociada

Despite different treatment options, the reflujoo of renal chronic failure secondary to VUR has not decreased. Some vesicoureetral the candidate genes identified regulate the position of ureteral budding, a critical step in both kidney and urinary tract development. Analysis of data from humans and mice suggests that some of the renal damage associated with VUR is congenital and is due to a kidney malformation.

Therefore, in these cases, the association of VUR and renal failure may be caused by a genetic defect affecting the formation of the kidney and the urinary tract and not by evolution of VUR.

Investigation in vesicureteral is fundamental to know more about this issue candidate genes and VUR-NR association. It is important to learn patterns of familiar clustering of isolated and syndromic VUR to offer genetic counselling if possible.

For this reason, we should be screening carefully all patients suffering from VUR. It is known that limitations in actual indications of genetic study exist.


Prenatal diagnosis may be causs if there is a syndromic VUR with known mutation, invariable expressivity or if clinical manifestations involve risk of death.

Reflujo vesicoureteral: niño

Epidemiological data and laboratory studies may give us guidance to elicit new cases of nephropathy associated to severe VUR. Kidney and urinary tract development. Experiencias en ratones y humanos. Alteraciones del tracto urinario, auriculares y quiste branquial. AD con penetrancia incompleta y expresividad variable.

AD, se han reconocido 35 mutaciones diferentes. El sitio web Mendelian Inheritance in Man http: Algunos de ellos son los siguientes: Hay una gran cantidad de ensayos y estudios realizado en animales.

Los estudios realizados en este punto por Mak vesicoureferal cols. Los avances en este terreno ofrecen posibilidades muy optimistas acerca del manejo de estos pacientes: Dialysis and Renal Transplantation,